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Updated: May 7, 2026

Generation of Oligodendrocytes and Oligodendrocyte-Conditioned Medium for Co-Culture Experiments
Published on: February 9, 2020
Canonical and non-canonical roles of oligodendrocyte precursor cells in mental disorders
Giulia Poggi1,2, Giulia Treccani3, Martina von der Bey4
1Institute of Anatomy, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany. poggigiu@uni-mainz.de.
Abstract:
Psychiatric research has shifted from a neuroncentric view to understanding mental disorders as disturbances of heterogeneous brain networks. Oligodendrocyte precursor cells (OPCs)- actively involved in the modulation of neuronal functions - are altered in psychiatric patients, but the extent and related consequences are unclear. This review explores canonical and non-canonical OPC-related pathways in schizophrenia, bipolar disorder, post-traumatic stress disorder, and depression in humans, highlighting potential mechanisms shared across diagnostic entities.
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