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A randomised trial of pleuran in paediatric acute gastroenteritis

Katarzyna Wzorek-Łyczko1, Anna Piwowarczyk2, Weronika Woźniak2

  • 1The Department of Pediatrics with Clinical Assessment Unit, Medical University of Warsaw, 63A Żwirki & Wigury Street, Warsaw, 02-091, Poland. katarzynawzorek@vp.pl.

Scientific Reports
|May 15, 2025
PubMed

Insights

Pleuran, a potential immunomodulator, did not effectively reduce the duration or severity of acute gastroenteritis in children. Further research is needed to explore its use as a nutraceutical in pediatric populations.

Area of Science:

  • Immunology
  • Pediatrics
  • Gastroenterology

Background:

  • Pleuran is recognized for its immunomodulatory properties and safety profile.
  • Its potential application in treating acute gastroenteritis, particularly in children, warrants investigation.

Purpose of the Study:

  • To evaluate the efficacy of Pleuran in reducing the duration and severity of acute infectious diarrhea in children.
  • To assess Pleuran's impact on hospitalization rates and need for intravenous rehydration.

Main Methods:

  • A multi-center, randomized, double-blind, placebo-controlled superiority trial.
  • Inclusion of children aged 2-10 years with acute gastroenteritis.
  • Primary outcome: duration of diarrhea. Secondary outcomes: severity, hospitalization, rehydration needs.

Main Results:

  • Twenty-seven children were enrolled in the study.
  • No statistically significant differences were observed between the Pleuran and placebo groups for diarrhea duration, hospital stay, intravenous rehydration, or symptom severity.
  • Pleuran administration was well-tolerated by all participants.

Conclusions:

  • Pleuran demonstrated ineffectiveness as a treatment for acute gastroenteritis in the studied pediatric population.
  • Further investigation is recommended to explore Pleuran's potential as a pediatric nutraceutical.

Keywords:
Beta-glucanInfectious diarrhoeaInnate immunityInterventional trial.Management of acute gastroenteritisMucosal immunity

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