The Consolidated Approach to Intervention Adaptation (CLARION): Developing and undertaking an empirically and...

Area of Science:

• Health Services Research
• Intervention Science
• Behavioral Science

Background:

• Intervention adaptation is crucial for resource-efficient implementation in new contexts.
• Existing adaptation frameworks lack detailed operational guidance and may not guarantee successful outcomes.
• Methodical approaches are needed to modify interventions without compromising efficacy.

Purpose of the Study:

• To develop and describe a step-by-step approach for intervention adaptation, named CLARION.
• To apply CLARION to adapt a depression self-management intervention.
• To identify facilitators and challenges encountered during the CLARION adaptation process.

Main Methods:

• CLARION was developed using Medical Research Council guidance, M-PACE, and a scoping review.
• The approach integrates intervention selection, core component identification, and stakeholder feedback.
• A two-stage process includes preliminary adaptation and pre-testing with stakeholders.

Main Results:

• CLARION facilitated clear articulation of core intervention components.
• A diverse steering committee, including patient partners, balanced input and efficiency.
• Key challenges involved defining modification types, committee involvement extent, and meeting attendance.

Conclusions:

• The developed CLARION approach offers detailed, step-by-step guidance for intervention adaptation.
• CLARION contributes to establishing best practices in intervention adaptation.
• Identifying facilitators and barriers aids in the successful application of adaptation frameworks.