H₂S Donor Functionalized Molecular Machine for Combating Multidrug-Resistant Bacteria Infected Chronic Wounds

Area of Science:

• Biomaterials Science
• Nanotechnology
• Wound Healing Research

Background:

• Chronic wounds present complex healing challenges, including bacterial infections, inflammation, and poor blood vessel formation.
• Current treatments struggle with bacterial drug resistance and controlling inflammation effectively.

Purpose of the Study:

• To develop a novel therapeutic strategy for chronic wounds that integrates antibacterial and anti-inflammatory actions.
• To address challenges in combating multidrug-resistant bacteria and achieving controlled therapeutic effects.

Main Methods:

• A hydrogen sulfide (H2S) donor-functionalized molecular machine (ACR-DM-HS) was synthesized.
• Light-activated vibronic-driven mechanochemical action (VDA) combined with photodynamic therapy (PDT) was employed for bacterial eradication.
• The molecular machine's ability to release H2S for anti-inflammatory and pro-angiogenic effects was investigated.

Main Results:

• ACR-DM-HS effectively eradicated multidrug-resistant bacteria and biofilms via VDA and PDT, overcoming bacterial resistance.
• Released H2S scavenged reactive oxygen species (ROS), reduced inflammation, and promoted angiogenesis.
• Accelerated healing of diabetic chronic wounds in vivo was observed.

Conclusions:

• The developed molecular machine offers an integrated approach for treating chronic wounds infected with multidrug-resistant bacteria.
• This strategy combines effective bacterial elimination with controlled anti-inflammatory effects to promote wound healing.