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Updated: May 17, 2025

Robotic Myotomy and Partial Fundoplication for Achalasia
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Bioengineering Innervated Esophagus With Improved Motility: Limitations and Future Directions.

Heather Wanczyk1, Joanne Walker1, Allan M Goldstein2

  • 1Department of Pediatrics, University of Connecticut Health Center, Farmington, Connecticut, USA.

Neurogastroenterology and Motility
|May 16, 2025
PubMed
Summary
This summary is machine-generated.

Bioengineered esophageal tissues show promise but lack innervation for motility. Innovations in 3D bioprinting, electrospinning, and AI are key to developing functional esophageal replacements with restored gut function.

Keywords:
enteric neural stem cellsinnervationmotilityperistalsissmooth muscle cellstissue engineered esophagus

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Area of Science:

  • Regenerative Medicine
  • Biomaterials Science
  • Gastroenterology

Background:

  • Esophageal tissue engineering has advanced using biomaterials and stem cells.
  • Current limitations include the lack of innervation and peristalsis in engineered tissues.
  • No stem cell therapies or esophageal substitutes currently restore esophageal motility.

Purpose of the Study:

  • Review advances and limitations in assessing esophageal motility in bioengineered tissues.
  • Highlight innovative technologies like 3D bioprinting, electrospinning, and AI for gut innervation.
  • Discuss future directions for patient-specific esophageal implants and equitable access.

Main Methods:

  • Literature review of current research in esophageal tissue engineering.
  • Analysis of assessment metrics for esophageal motility.
  • Exploration of emerging technologies and neuronal cellular approaches.

Main Results:

  • Significant progress in biomaterials and stem cell integration for tissue structure and function.
  • Identified a critical gap in achieving functional innervation and peristalsis.
  • Highlighted the potential of 3D bioprinting, electrospinning, and AI in addressing this gap.

Conclusions:

  • Achieving functional innervation is crucial for restoring esophageal motility in bioengineered replacements.
  • Innovative technologies offer promising avenues for developing clinically viable esophageal therapies.
  • Patient-specific implants and equitable access are vital for future clinical translation.