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Updated: May 17, 2025
08:14
Characterization of Leukocyte-platelet Rich Fibrin, A Novel Biomaterial
Published on: September 29, 2015
12.9K
Platelet Rich Products in Cleft Palate Repair
Samer T Elsamna1, Fayssal Alqudrah2, Mahnoor Khan1
1Department of Otolaryngology-Head and Neck Surgery, Morsani College of Medicine of the University of South Florida, Tampa, FL, USA.
Summary
Platelet-rich products (PRPs) significantly reduced fistula rates in cleft palate repairs. This meta-analysis suggests PRPs are an effective adjunct for improving surgical outcomes in palatoplasty.
Area of Science:
- Surgical Innovation
- Regenerative Medicine
- Craniofacial Surgery
Background:
- Cleft palate (CP) repair has numerous techniques, yet fistula rates remain high (15-55%).
- Platelet-rich products (PRPs) are known for accelerating wound healing.
- Evaluating PRPs' impact on fistula formation post-CP repair is crucial.
Purpose of the Study:
- To systematically review and meta-analyze the effect of PRPs on fistula rates after primary or secondary cleft palate repair.
- To assess the efficacy of PRPs as an adjunct in CP surgical management.
Main Methods:
- A systematic meta-analysis review of randomized controlled trials.
- Searched multiple databases including MEDLINE, Embase, Pubmed, and Scopus.
- Included 164 patients undergoing primary or secondary CP repair, comparing PRP vs. no PRP.
Main Results:
- Five studies with 164 patients were analyzed.
- Fistula rates were 4.9% in the PRP group and 22.0% in the non-PRP group.
- PRP use showed a statistically significant reduction in fistula rates (pooled risk ratio: 0.32, p=0.02).
Conclusions:
- Platelet-rich products (PRPs) significantly reduce fistula rates following cleft palate repair.
- PRPs may serve as an effective intra-operative adjunct to conventional CP surgery.
- Further research is needed to explore PRP's impact on other post-operative parameters in CP repair.
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