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Related Concept Videos

T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

596
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
596
Cells of the Adaptive Immune Response01:23

Cells of the Adaptive Immune Response

694
The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
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Related Experiment Video

Updated: May 17, 2025

In Vitro Differentiation Model of Human Normal Memory B Cells to Long-lived Plasma Cells
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Surface CD69-Negative CD4 and CD8 Bone Marrow-Resident Human Memory T Cells.

Emilia Schneider Revueltas1, Marta Ferreira-Gomes1, Gabriela Maria Guerra1

  • 1Deutsches Rheuma-Forschungszentrum Berlin, ein Institut der Leibniz Gemeinschaft, Berlin, Germany.

European Journal of Immunology
|May 16, 2025
PubMed
Summary
This summary is machine-generated.

CD69-negative memory T cells in bone marrow are tissue-resident, not circulating. They remain in the bone marrow due to CD69 and S1PR1 interactions, despite expressing S1PR1.

Keywords:
CD69T cell receptor repertoirebone marrowmemory T lymphocytestranscriptome

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Area of Science:

  • Immunology
  • Cell Biology

Background:

  • Tissue-resident memory T cells typically express CD69 and lack S1PR1.
  • The residency of CD69-negative memory T cells in tissues like bone marrow is not well understood.

Purpose of the Study:

  • To investigate the residency and characteristics of CD69-negative memory T cells in human bone marrow compared to blood.
  • To elucidate the molecular mechanisms maintaining these cells in the bone marrow.

Main Methods:

  • Comparative analysis of transcriptomes and T cell receptor (TCR) repertoires of individual CD4 and CD8 memory T cells from paired blood and bone marrow samples.
  • Analysis of gene expression for CD69 and S1PR1 in bone marrow memory T cells.

Main Results:

  • CD69-negative memory T cells from blood and bone marrow share transcriptional profiles, indicating common origins.
  • Distinct TCR repertoires in bone marrow versus blood CD69-negative memory T cells suggest compartmentalization and bone marrow residency.
  • Bone marrow CD69-negative memory T cells express CD69 and S1PR1, with evidence of CD69/S1PR1 dimerization and internalization.

Conclusions:

  • CD69-negative memory T cells in bone marrow are tissue-resident, not circulating.
  • CD69-S1PR1 interactions in bone marrow T cells likely prevent S1P-mediated egress, retaining them within the tissue.