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Related Experiment Videos

Reversible monocular cataract simulating amaurosis fugax.

R R Paylor, J B Selhorst, R S Weinberg

    Annals of Ophthalmology
    |July 1, 1985
    PubMed
    Summary

    Recurrent transient monocular visual loss in a diabetic patient was linked to fluctuating serum glucose levels. This was identified as a reversible cataract caused by osmotic shifts within the eye lens.

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    Area of Science:

    • Ophthalmology
    • Endocrinology
    • Diabetology

    Background:

    • Juvenile-onset diabetes presents complex metabolic challenges.
    • Transient monocular visual loss (amaurosis fugax) is a known complication.
    • Significant serum glucose fluctuations can impact various bodily systems.

    Observation:

    • A patient with brittle diabetes experienced recurrent, prolonged monocular visual loss.
    • Visual loss correlated with wide serum glucose fluctuations.
    • Direct observation revealed lens opacification without pupillary defects.

    Findings:

    • The visual loss was attributed to a reversible cataract.
    • Hyperosmotic gradients, due to glucose and sorbitol accumulation, drew water into the lens.
    • Hypoglycemia may have contributed to osmotic gradient formation.
    • Unilateral presentation linked to asymmetric posterior subcapsular cataract permeability.

    Implications:

    • Highlights a novel presentation of diabetic ocular complications.
    • Suggests osmotic cataracts can manifest as prolonged visual disturbances.
    • Emphasizes the critical role of glycemic control in preventing vision loss in diabetics.

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