Related Experiment Video
Updated: May 17, 2025

Vinyl Chloride and High-Fat Diet as a Model of Environment and Obesity Interaction
Published on: January 12, 2020
Health risks of N,N-dimethylacetamide (DMAC) in humans
Tetsuo Nomiyama1,2,3,4, Teruomi Tsukahara2,3,4, Kohei Hasegawa1,2,3
1Department of Preventive Medicine and Public Health, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto, Nagano 390-8621, Japan.
Abstract:
N,N-Dimethylacetamide (DMAC), which is widely used as an industrial solvent, can be absorbed via the respiratory tract and skin of humans exposed to it. Hepatotoxicity is a main health risk of DMAC exposure in humans, and the relevant cases and epidemiological studies are reviewed herein. No hepatotoxicity was identified in workers exposed to ~3 ppm DMAC, and among workers exposed to >9 ppm DMAC the DMAC exposure was not observed to contribute significantly to liver damage. However, a case of liver damage was identified in which the calculated 8-hour weighted average was 12.8 mg/m3 (3.6 ppm). The skin absorption notation for DMAC is indicated based on human volunteer studies. The evidence regarding DMAC's potential carcinogenicity in humans is not sufficient, and our literature search identified no report of DMAC as a reproductive toxicant in humans. Further case reports and epidemiological studies are necessary to determine the acceptable DMAC exposure limit for workers and thus protect them from DMAC's toxicity.
More Related Videos
Related Concept Videos
Stress Prevention and Stress Management Techniques IV
Types of Toxins
Air pollutants, primarily gases, pose significant threats to respiratory health, leading to conditions like hypoxia, lung cancer, and in extreme cases, death.
Environmental pollutants like...
Biological Effects of Radiation
Lifestyle Factors and Health
Benefits of Physical Activity
Physical activity, whether through structured exercise or casual activities like walking, biking, or dancing, is a cornerstone of a...
Pulmonary Tuberculosis I
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Factors Affecting the Risk of Infection
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...

