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Function of hematopoiesis and bone marrow niche in inflammation and non-hematopoietic diseases

Yu-Xiang Wang1,2,3, Zhao-Hua Deng1,2,3, Yu-Yan Li1,2,3

  • 1Center for Cell Lineage Atlas, Joint School of Life Sciences, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou Medical University, Guangzhou 510530, China.

Life Medicine
|May 16, 2025
PubMed

Hematopoiesis and the behavior of hematopoietic stem and progenitor cells (HSPCs) are regulated by the bone marrow niche. Here, we introduce the major niche cell types in bone marrow and their response to stress condition. We highlight the hematopoietic response and bone marrow niche adaptation to inflammatory condition and non-hematopoietic diseases, which are not systematically summarized. These emerging data suggest targeting hematopoiesis and bone marrow niche may provide novel therapeutic target to precisely control the progression of the diseases.

Keywords:
bone marrow nichehematopoiesishematopoietic stem and progenitor cellinflammation

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