Autoimmune Hepatitis (AIH) Related to Drug-Induced Liver Injury (DILI) Due to Atorvastatin

Drug-induced liver injury (DILI) is a rare condition characterized by hepatotoxic damage, identified through the elevation of liver function tests associated with a specific drug. Statins are among the medications linked to DILI, although this association is infrequent. Recently, reports and case series have described a relationship between atorvastatin-induced DILI and autoimmune hepatitis (AIH), two conditions not commonly associated. Because there are no established clinical or diagnostic criteria for this overlap, recognition is complex and relies on the clinical course, a timeline of causality, and the exclusion of alternative diagnoses. This report presents the case of a patient in the seventh decade of life who developed atorvastatin-induced DILI, meeting the diagnostic criteria for AIH. We discuss the therapeutic approach and review the relevant literature on this rare association.