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Hyperactive Catatonia in an Adolescent With Prader-Willi Syndrome
Rame Alharbi1, Saeed S Shaaban1, Eric MacMaster1
1Department of Psychiatry, State University of New York Upstate Medical University, Syracuse, USA.
Cureus
|May 16, 2025
Summary
Catatonia is a serious neuropsychiatric complication in Prader-Willi syndrome (PWS). This case study shows lorazepam effectively treated hyperactive catatonia in an adolescent with PWS.
Area of Science:
- Neuropsychiatry
- Genetics
- Pediatrics
Background:
- Prader-Willi syndrome (PWS) is a complex genetic disorder with diverse clinical manifestations.
- Catatonia, a neuropsychiatric syndrome, is an emerging complication in PWS, yet under-researched, especially in pediatric cases.
Observation:
- A case of hyperactive catatonia in an adolescent with Prader-Willi syndrome is presented.
- The patient exhibited a progression from motor symptoms to psychotic features.
Findings:
- Lorazepam was administered in multiple doses.
- Lorazepam demonstrated consistent effectiveness in resolving catatonic symptoms during hospitalization.
Implications:
- This case highlights the importance of recognizing and managing catatonia in pediatric PWS.
- Further research into catatonia in PWS is warranted to improve diagnostic and therapeutic strategies.
- Prompt treatment with benzodiazepines like lorazepam can be beneficial for catatonia in PWS.
Keywords:
agitationbehavior changecatatoniachild and adolescent psychiatryhyperactive catatoniapediatric geneticsprader-williprader-willi syndromeMore Related Videos
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