RND/HAE-1 members in the Pseudomonadota phylum: exploring multidrug resistance

Area of Science:

• Microbiology
• Molecular Biology
• Biochemistry

Background:

• The hydrophobe/amphiphile efflux-1 (HAE-1) family is a key component of the Resistance-Nodulation-Division (RND) superfamily in bacteria.
• These efflux pumps are crucial for developing multidrug resistance (MDR) by expelling diverse toxic compounds.

Purpose of the Study:

• To review current knowledge on HAE-1 efflux transporters.
• To elucidate their roles in the physiology and survival of bacteria within the Pseudomonadota phylum.

Main Methods:

• Literature review of existing research on HAE-1 efflux systems.
• Analysis of the structure and function of HAE-1 transporters and associated proteins (MFPs, OMFs).

Main Results:

• HAE-1 efflux systems are prevalent in Pseudomonadota (Proteobacteria) and linked to increased bacterial resistance and virulence.
• Well-studied examples like AcrAB-TolC in *Escherichia coli* and MexAB-OprM in *Pseudomonas aeruginosa* demonstrate efficient substrate transport.

Conclusions:

• HAE-1 efflux transporters are vital for bacterial adaptation and survival in challenging environments.
• Understanding these systems is critical for combating MDR in priority pathogens.