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Related Concept Videos

Bioremediation00:46

Bioremediation

Bioremediation is the use of prokaryotes, fungi, or plants to remove pollutants from the environment. This process has been used to remove harmful toxins in groundwater as a byproduct of agricultural run-off and also to clean up oil spills.
Environmental Applications of Microorganisms01:30

Environmental Applications of Microorganisms

Microorganisms play a pivotal role in maintaining ecosystem balance by recycling essential elements such as carbon, nitrogen, and phosphorus, as well as supporting processes like bioremediation, wastewater treatment, and biofuel production.Microbes in Elemental CyclesIn the carbon cycle, microorganisms decompose organic matter, releasing carbon dioxide via aerobic respiration. This carbon dioxide is subsequently used by photosynthetic organisms to synthesize organic compounds, closing the...
Microbial Bioremediation of Pesticides01:28

Microbial Bioremediation of Pesticides

Pesticides often feature structurally complex chemical architectures, incorporating halogen groups and multiple aromatic rings. These characteristics confer high chemical stability, rendering many pesticides resistant to natural degradation processes. This resistance poses significant environmental concerns, as persistent pesticide residues can accumulate in ecosystems and affect non-target organisms.Despite the inherent stability of many pesticides, certain microorganisms possess the metabolic...
Microbial Fuel Cells01:23

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Microbial fuel cells (MFCs) are bioelectrochemical devices that generate electricity by exploiting the metabolic processes of electrogenic bacteria. These systems provide a renewable energy source and serve as an innovative method for treating organic waste, such as wastewater.A typical MFC consists of two chambers: an anoxic (oxygen-free) compartment that houses the bacteria and an oxic (oxygen-rich) compartment that contains oxygen as the terminal electron acceptor. Many MFCs use proton...
Bioplastics01:27

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Bioplastics derived from microbial processes present a sustainable alternative to conventional petroleum-based plastics. Among these, polyhydroxyalkanoates (PHAs), particularly polyhydroxybutyrates (PHBs), have emerged as prominent candidates due to their biodegradability and biocompatibility. These polymers are synthesized by a variety of bacteria, such as Cupriavidus necator and Pseudomonas putida, which naturally accumulate PHAs as intracellular carbon and energy reserves, especially under...
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Polyethylene terephthalate (PET) is a synthetic polymer widely utilized in the packaging industry, particularly for bottles and containers. Due to its chemical stability and durability, PET accumulates in the environment, contributing significantly to plastic pollution. It comprises repeating units of terephthalic acid and ethylene glycol, resulting in a semi-crystalline structure that is resistant to natural degradation processes.A notable breakthrough in plastic biodegradation came with the...

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Updated: Jun 27, 2026

Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing
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Biodegradable Oxygen-Generating Microneedle Patches for Regenerative Medicine Applications.

Lindsay Barnum1,2, Mohamadmahdi Samandari1, Yasir Suhail1,2

  • 1Department of Biomedical Engineering University of Connecticut Health Center Farmington CT 06030 USA.

Advanced Nanobiomed Research
|May 16, 2025
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Summary

Biodegradable microneedle arrays deliver oxygen to enhance wound healing. These novel oxygen-generating microneedle arrays improve cell viability in hypoxic conditions and promote tissue repair without harming skin.

Keywords:
GelMAbiomaterialsmicroneedlesoxygen‐generating materialswound healing

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Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Wound Healing Research

Background:

  • Skin regeneration requires oxygen, but chronic wounds often exhibit hypoxia, impairing healing.
  • Microneedle arrays (MNAs) can improve therapeutic delivery, but oxygen-releasing variants face manufacturing and byproduct challenges.
  • Existing oxygen-releasing MNAs are complex and may produce cytotoxic byproducts, limiting their clinical applicability.

Purpose of the Study:

  • To develop and optimize biodegradable gelatin methacryloyl-based microneedle arrays (MNAs) for effective oxygen release in wound environments.
  • To evaluate the oxygen release kinetics, biocompatibility, and therapeutic potential of these novel MNAs in vitro and in vivo.
  • To investigate the molecular mechanisms underlying the wound healing benefits of oxygen-generating MNAs.

Main Methods:

  • Fabrication of biodegradable gelatin methacryloyl-based MNAs with varying compositions.
  • Assessment of oxygen release rates upon contact with simulated interstitial fluid and wound exudates.
  • In vitro evaluation of cell viability under hypoxic conditions using optimized MNAs.
  • In vivo assessment of MNA safety and efficacy in a murine model of acute skin injury.
  • Transcriptomic analysis to elucidate the molecular pathways affected by MNA treatment.

Main Results:

  • Optimized MNAs demonstrated controlled oxygen release at therapeutic levels.
  • In vitro studies showed significantly increased viability of hypoxic cells treated with optimized MNAs.
  • In vivo studies confirmed MNA safety, showing no adverse effects on acute skin wound healing in mice.
  • Transcriptomic analysis revealed enhanced fibroblast motility, altered lipid metabolism, and reduced inflammatory signaling.

Conclusions:

  • Biodegradable, oxygen-generating MNAs offer a promising solution for overcoming hypoxia in wound healing.
  • The developed MNAs are biocompatible, effective in delivering therapeutic oxygen levels, and promote wound repair.
  • This strategy presents a novel approach for treating chronic wounds by addressing hypoxic conditions and modulating key healing pathways.