Skeletal Muscle Tissue Engineering: From Tissue Regeneration to Biorobotics

Area of Science:

• Biomedical Engineering
• Regenerative Medicine
• Robotics

Background:

• Skeletal muscle's adaptability inspires engineering and robotics.
• Skeletal muscle tissue engineering (SMTE) originated for clinical needs but now extends to biorobotics.
• The field integrates regenerative medicine with engineering principles.

Purpose of the Study:

• To review recent advancements in skeletal muscle tissue engineering (SMTE).
• To explore the synergies between SMTE and robotics.
• To highlight the development of biohybrid devices and novel technologies.

Main Methods:

• Review of innovations in scaffold design and cell sourcing for SMTE.
• Analysis of external physicochemical cues and bioreactor technologies.
• Exploration of robotic systems enhancing bioreactor performance.

Main Results:

• Significant progress in SMTE techniques and materials.
• Emerging integration of SMTE with robotic systems.
• Development of biohybrid devices incorporating engineered muscle tissue.

Conclusions:

• SMTE offers versatile strategies beyond medical applications.
• Interdisciplinary approaches enhance functional recovery and inspire new biohybrid technologies.
• The intersection of engineering and regenerative medicine is a rapidly growing field.