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Cytidine deaminase--a marker for pre-eclampsia?

T J Baines, A Clark

    Annals of Clinical Biochemistry
    |July 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

    Elevated cytidine deaminase (cytidine aminohydrolase) activity in pregnancy shows poor correlation with pre-eclampsia. Many normal pregnancies exhibit false positive enzyme elevations, limiting its diagnostic value.

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    Area of Science:

    • Biochemistry
    • Clinical Chemistry
    • Obstetrics

    Background:

    • Cytidine deaminase (cytidine aminohydrolase, EC 3.5.4.5) is an enzyme involved in nucleotide metabolism.
    • Its potential role in pregnancy complications like pre-eclampsia warrants investigation.

    Purpose of the Study:

    • To assess the correlation between cytidine deaminase activity and pre-eclampsia in pregnant women.
    • To determine the diagnostic utility of cytidine deaminase as a biomarker for pre-eclampsia.

    Main Methods:

    • Blood samples were collected from 590 unselected pregnant women during routine antenatal monitoring.
    • Cytidine deaminase activity was measured in serum without knowledge of clinical status.
    • Enzyme levels were compared between patients with severe pre-eclampsia, mild pre-eclampsia, and normal pregnancies.

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    Main Results:

    • Increased cytidine deaminase activity was observed in 42.9% of severe pre-eclampsia cases.
    • Elevated activity was also found in 9.1% of mild pre-eclampsia cases and 8.6% of normal pregnancies.
    • A significant proportion of normal pregnancies showed elevated enzyme activity, indicating a high false positive rate.

    Conclusions:

    • Cytidine deaminase activity demonstrates a poor correlation with the presence or severity of pre-eclampsia.
    • The high rate of false positive results in normal pregnancies limits its usefulness as a reliable biomarker for pre-eclampsia detection.