Expression Profile of Serum CircFUNDC1 and CircUHRF1 Can Differentiate Between Colorectal Cancer and Inflammatory Bowel Diseases (Ulcerative Colitis and Crohn's Disease)
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View abstract on PubMed
Summary
This summary is machine-generated.Serum CircFUNDC1 is a promising biomarker for colorectal cancer (CRC), while CircUHRF1 indicates inflammatory bowel disease (IBD). Both circular RNAs show diagnostic potential in Egyptian patients.
Area Of Science
- Biochemistry
- Molecular Biology
- Oncology
Background
- Colorectal cancer (CRC) poses a significant global health challenge.
- Circular RNAs (circRNAs) are emerging as valuable biomarkers for CRC diagnosis and prognosis.
Purpose Of The Study
- To assess the association between serum levels of CircFUNDC1 and CircUHRF1 and the predisposition and clinicopathological features of CRC, ulcerative colitis (UC), and Crohn's disease (CD) in Egyptian patients.
- To evaluate the diagnostic potential of these circRNAs in differentiating between these conditions and healthy controls.
Main Methods
- Quantitative polymerase chain reaction (qPCR) was employed to measure serum levels of CircFUNDC1 and CircUHRF1.
- The study included 113 Egyptian subjects: 31 with CRC, 26 with UC, 25 with CD, and 31 healthy controls.
- Receiver Operating Characteristic (ROC) curve analysis was used to determine the diagnostic accuracy.
Main Results
- CircFUNDC1 was significantly upregulated in patients with CRC, UC, and CD compared to healthy controls (p < 0.001).
- CircUHRF1 was significantly overexpressed in patients with UC and CD compared to CRC patients and controls (p < 0.001), but showed no significant difference in CRC patients versus controls.
- Both circRNAs demonstrated the ability to differentiate CRC patients from inflammatory bowel disease (IBD) patients or healthy controls (p < 0.05).
Conclusions
- Serum CircFUNDC1 serves as a potential biomarker for colorectal cancer.
- Serum CircUHRF1 is identified as a potential biomarker for inflammatory bowel disease.
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