Premature ovarian insufficiency: addressing the most controversial issues

Area of Science:

• Reproductive Endocrinology
• Women's Health
• Clinical Guidelines

Background:

• Premature ovarian insufficiency (POI) is a significant health concern with higher global prevalence than previously estimated.
• The condition profoundly impacts sufferers' quality of life and long-term well-being.
• POI has historically been a neglected area in medical research and awareness.

Purpose of the Study:

• To provide a state-of-the-art commentary on key controversial topics in premature ovarian insufficiency (POI).
• To highlight how current challenges in POI are being addressed and identify future research directions.
• To emphasize the need for increased awareness and improved clinical management of POI.

Main Methods:

• The content is based on a commentary delivered as the Pieter Van Keep oration at the 2024 International Menopause Society (IMS) Congress.
• It draws upon the recent update of the European Society of Human Reproduction (ESHRE) POI guideline.
• The commentary focuses on critical discussion of controversial aspects rather than a systematic literature review.

Main Results:

• The recent ESHRE guideline update, a collaborative effort, is expected to enhance the clinical management of POI.
• The guideline development process identified critical research gaps where current data is insufficient for definitive guidance.
• Key controversial topics in POI were highlighted, necessitating further investigation and discussion.

Conclusions:

• There is a growing awareness of premature ovarian insufficiency (POI) due to recent guideline updates and collaborative efforts.
• Significant research is still needed to address knowledge gaps and improve the management of POI.
• Addressing controversial topics in POI is crucial for improving the lives of affected individuals and their families.