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Updated: May 17, 2025

A Protocol for Computer-Based Protein Structure and Function Prediction
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LIGYSIS-web: a resource for the analysis of protein-ligand binding sites

Javier S Utgés1, Stuart A MacGowan1, Geoffrey J Barton1

  • 1Division of Computational Biology, School of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH Scotland, UK.

Nucleic Acids Research
|May 16, 2025
PubMed

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Allosteric proteins have more than one ligand binding site; the binding of a ligand to any of these sites influences the binding of ligands to the other sites. When a protein is allosteric, its binding sites are called coupled or linked.  In the case of enzymes, the site that binds to the substrate is known as the active site and the other site is known as the regulatory site. When a ligand binds to the regulatory site, this leads to conformational changes in the protein that can influence...
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