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Related Experiment Video

Updated: Jun 11, 2026

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Published on: December 11, 2017

Leadless Atrial Pacing Targeting Bachmann's Bundle for Atrial Resynchronization.

Zachary Hollis¹, Eunice Yang², Kyungmoo Ryu³

¹Inova Schar Heart and Vascular, Falls Church, Virginia, USA.

JACC. Case Reports

|May 16, 2025

Summary

This study introduces leadless Bachmann's bundle area pacing (BBAP) as a novel method for atrial resynchronization. Leadless BBAP enhances atrial synchrony and may reduce the risk of atrial fibrillation.

Keywords:

atrial fibrillation atrial resynchronization bachmann's bundle pacing interatrial conduction delay leadless atrial pacing sinus node dysfunction

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Last Updated: Jun 11, 2026

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Area of Science:

Cardiology
Electrophysiology
Medical Devices

Background:

Leadless pacemakers offer advantages over traditional pacing by reducing infection and lead complications.
The feasibility of leadless pacing specifically targeting Bachmann's bundle area (BBAP) for atrial resynchronization remains unexplored.

Observation:

A first-in-human case involved a 49-year-old woman with sinus node dysfunction and interatrial conduction delay.
A leadless atrial pacemaker was successfully implanted in the Bachmann's bundle region using intracardiac echocardiography and electrographic mapping.

Findings:

The implantation resulted in reduced right atrium-to-lateral left atrium conduction time.
Paced P wave duration was confirmed to be shorter, indicating improved atrial synchrony.

Implications:

Leadless BBAP presents a physiological approach to atrial conduction system pacing.
This technique may improve atrioventricular dromotropy and potentially decrease the incidence of atrial fibrillation compared to right atrial appendage pacing.