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Highly Convergent Modular Access to Carbonylative Difunctionalized Cyclopropanes via Palladium-Catalyzed
Xuening Li1, Suliang Wang1, Jian Song1,2
1Key Laboratory of Organosilicon Chemistry and Material Technology of Ministry of Education, Zhejiang Key Laboratory of Organosilicon Material Technology, College of Material, Chemistry and Chemical Engineering, Hangzhou Normal University, 2318 Yuhangtang Road, Hangzhou 311121, China.
Abstract:
A novel and efficient synthesis of carbonylative difunctionalized cyclopropanes was disclosed by the palladium-catalyzed thioether-thiocarbonylation of cyclopropenes with organic disulfides. Preliminary studies show that the electron-rich unit in organic disulfide was more conducive to the production of the thioesters. This process is applicable to a series of cyclopropane derivatives and employs commercially available diaryl disulfides as the partners. Notably, the gram-scale reaction and further transformations demonstrate the practicality and application potential of this approach for organic synthesis.
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