Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Equilibrium and Balance01:15

Equilibrium and Balance

4.3K
The inner ear assumes dual functionalities of auditory perception and equilibrium maintenance. The vestibule is the organ responsible for balance. This organ contains mechanoreceptors, specifically hair cells, endowed with stereocilia, which aid in deciphering information regarding the position and motion of our heads. Two intrinsic components, the utricle and saccule, help perceive head position, while the semicircular canals track head movement. Neurological messages initiated in the...
4.3K
Insulin: Dosing Regimen and Adverse Effects01:16

Insulin: Dosing Regimen and Adverse Effects

129
Insulin-replacement therapy usually includes both long-acting insulin (basal) and short-acting insulin (to cater to postprandial needs). In a diverse group of type 1 diabetes patients, the average daily insulin dose is typically 0.5-0.7 units/kg body weight. However, obese patients and pubertal adolescents may need more due to insulin resistance.
The basal dose constitutes about 40%-50% of the total daily dose, with the rest as premeal insulin. The mealtime insulin dose should mirror...
129
Hormones Regulating Blood Glucose01:16

Hormones Regulating Blood Glucose

2.9K
Insulin is released by beta cells of the pancreas when blood glucose levels are high. It facilitates glucose absorption and utilization in insulin-dependent cells with insulin receptors on their plasma membranes. Insulin promotes glucose uptake by increasing the number of glucose transport proteins in the cell membrane, allowing glucose to enter the cell. As a result, glucose utilization and ATP production are enhanced.
In addition to accelerating glucose uptake and utilization, insulin has...
2.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

NEP89: universal neuroevolution potential for inorganic and organic materials across 89 elements.

Nature computational science·2026
Same author

Seconds-scale exfoliation of high-quality 2D crystals enabled by polycyclic aromatic hydrocarbon radical anion-mediated organoalkali intercalation.

Nature communications·2026
Same author

Enhancing Whole Slide Image Classification in Renal Cell Carcinoma via Swin Transformer-Based Multiple Instance Learning.

Bioengineering (Basel, Switzerland)·2026
Same author

Characterization of sexually acquired HIV-1 transmission networks and genetic variation in northern frontier China, 2021-2024.

Frontiers in public health·2026
Same author

Preoperative prediction of early recurrence and microvascular invasion in hepatocellular carcinoma using conventional ultrasound, elastography, and clinical nutritional indicators: a radiomics-based study.

American journal of translational research·2026
Same author

What do cancer patients discuss online regarding CINV management? A social media-based topic modeling study.

Frontiers in oncology·2026

Related Experiment Video

Updated: May 17, 2025

Assessing the Autonomic and Behavioral Effects of Passive Motion in Rats using Elevator Vertical Motion and Ferris-Wheel Rotation
06:18

Assessing the Autonomic and Behavioral Effects of Passive Motion in Rats using Elevator Vertical Motion and Ferris-Wheel Rotation

Published on: February 7, 2020

6.6K

Insulin level regulators may affect cognitive ability caused by motion sickness: an experimental study.

Mengyu Zhong1, Jian Zhu1,2, Bohan Zhang1,3

  • 1Department of Naval Nutrition and Food Hygiene, Faculty of Navy Medicine, Naval Medical University, 800 Xiangyin Rd, Yangpu District, Shanghai, 200433, China.

Metabolic Brain Disease
|May 16, 2025
PubMed
Summary

Motion sickness (MS) impairs cognitive function. This study reveals that insulin and its regulators can significantly reduce MS symptoms and improve cognitive abilities, offering new therapeutic insights.

Keywords:
Cognitive impairmentInsulinMetaboliteMotion sickness

More Related Videos

Osmotic Minipump Implantation for Increasing Glucose Concentration in Mouse Cerebrospinal Fluid
06:21

Osmotic Minipump Implantation for Increasing Glucose Concentration in Mouse Cerebrospinal Fluid

Published on: April 7, 2023

1.3K
Studying the Hypothalamic Insulin Signal to Peripheral Glucose Intolerance with a Continuous Drug Infusion System into the Mouse Brain
08:32

Studying the Hypothalamic Insulin Signal to Peripheral Glucose Intolerance with a Continuous Drug Infusion System into the Mouse Brain

Published on: January 4, 2018

10.2K

Related Experiment Videos

Last Updated: May 17, 2025

Assessing the Autonomic and Behavioral Effects of Passive Motion in Rats using Elevator Vertical Motion and Ferris-Wheel Rotation
06:18

Assessing the Autonomic and Behavioral Effects of Passive Motion in Rats using Elevator Vertical Motion and Ferris-Wheel Rotation

Published on: February 7, 2020

6.6K
Osmotic Minipump Implantation for Increasing Glucose Concentration in Mouse Cerebrospinal Fluid
06:21

Osmotic Minipump Implantation for Increasing Glucose Concentration in Mouse Cerebrospinal Fluid

Published on: April 7, 2023

1.3K
Studying the Hypothalamic Insulin Signal to Peripheral Glucose Intolerance with a Continuous Drug Infusion System into the Mouse Brain
08:32

Studying the Hypothalamic Insulin Signal to Peripheral Glucose Intolerance with a Continuous Drug Infusion System into the Mouse Brain

Published on: January 4, 2018

10.2K

Area of Science:

  • Neuroscience
  • Endocrinology
  • Physiology

Background:

  • Abnormal acceleration induces motion sickness (MS), leading to cognitive impairments.
  • The precise mechanisms underlying MS-induced cognitive deficits remain largely unknown.

Purpose of the Study:

  • To investigate the role of insulin and related metabolic factors in motion sickness and associated cognitive dysfunction.
  • To explore potential therapeutic interventions targeting insulin pathways for MS.

Main Methods:

  • Analysis of blood metabolites, hormones (insulin, leptin, ghrelin), and cytokines in humans and rats exposed to acceleration.
  • Correlation analysis between motion sickness index (MSI) and physiological markers.
  • Pharmacological interventions using insulin regulators, ghrelin, and ghrelin antagonists in rat models.
  • Assessment of cognitive function using behavioral tests (Open Field, T-maze, Morris water maze) and molecular analysis (hippocampal protein expression).

Main Results:

  • Elevated blood glucose and decreased insulin/leptin, increased ghrelin levels were observed post-acceleration.
  • Insulin administration significantly reduced MSI, while ghrelin exacerbated MS symptoms.
  • Acceleration induced insulin receptor substrate 1 (IRS1) phosphorylation in the hippocampus.
  • Hippocampal insulin microinjection ameliorated MS symptoms and improved cognitive performance.

Conclusions:

  • Insulin plays a critical role in modulating motion sickness severity and cognitive function.
  • Insulin level regulators demonstrate potential as therapeutic agents for motion sickness and related cognitive impairments.