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Updated: May 20, 2025

In Vivo Immunogenicity Screening of Tumor-Derived Extracellular Vesicles by Flow Cytometry of Splenic T Cells
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Specific signaling pathways mediated programmed cell death in tumor microenvironment and target therapies

Chengpeng Sun1,2, Jiawei Gui1,2, Yilei Sheng1,2

  • 1The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, No.1, Minde Road, Donghu District, Nanchang, 330006, Jiangxi, China.

Discover Oncology
|May 16, 2025
PubMed

Insights

Programmed cell death (PCD) mechanisms like apoptosis and necroptosis are vital in cancer. Targeting key signaling pathways offers new therapeutic strategies for improved cancer treatment outcomes.

Area of Science:

  • Oncology
  • Cell Biology
  • Molecular Biology

Background:

  • Programmed cell death (PCD) is integral to tumorigenesis and cancer progression.
  • PCD encompasses diverse, interconnected mechanisms including apoptosis, necroptosis, alkaliptosis, oxeiptosis, and anoikis.

Purpose of the Study:

  • To comprehensively review the multifaceted nature of PCD.
  • To elucidate the regulatory mechanisms of key signaling pathways in PCD and tumor progression.

Main Methods:

  • Description of the generation mechanisms of different PCD components.
  • Focus on the regulatory roles of caspase, RIPK1/RIPK3/MLKL, and mTOR signaling pathways in global PCD.

Main Results:

  • Detailed examination of the interplay between PCD pathways and tumor development.
  • Identification of therapeutic compounds targeting specific signaling axes within these pathways.

Conclusions:

  • Understanding PCD signaling is crucial for developing novel cancer therapies.
  • Targeting PCD pathways presents promising strategies to enhance tumor treatment efficacy and patient outcomes.
Keywords:
CaspaseMLKLMTORProgrammed cell deathRIPK1RIPK3Tumor

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