Unusual case of non-sexual Mpox transmission in a heterosexual woman

Monkeypox (MPOX) is becoming an important differential diagnosis in non-endemic regions, particularly in patients with atypical dermatologic lesions and systemic symptoms. Although it is more commonly associated with males, it is important to consider MPOX in females, as its presentation may be misattributed to more common infections. This article describes a 28-year-old heterosexual female with cutaneous lesions and systemic symptoms that were initially thought to be a localized infection. Further evaluation confirmed MPOX with a bacterial superinfection. The patient had no sexual but close contact with a confirmed case of MPOX. Clinicians must remain vigilant to recognize the broad spectrum of MPOX presentations and ensure timely diagnosis, isolation, and preventive measures to limit transmission.