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Related Concept Videos

Multiple Sclerosis l: Introduction01:19

Multiple Sclerosis l: Introduction

Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...

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Related Experiment Video

Updated: Jun 5, 2026

Dissociation of the Confounding Influences of Expectancy and Integrative Difficulty Residing in Anomalous Sentences in Event-related Potential Studies
05:22

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Cognitively stimulating activities in multiple sclerosis: A qualitative feasibility study.

Andreas Kirknæs Færk1, Jakob Lindegaard Lund1, Finn Sellebjerg1,2

  • 1Danish Multiple Sclerosis Center, Department of Neurology, Copenhagen University Hospital - Rigshospitalet, Glostrup, Denmark.

Neuropsychological Rehabilitation
|May 16, 2025
PubMed
Summary
This summary is machine-generated.

An intervention to increase cognitively stimulating activities (CSAs) is feasible for people with multiple sclerosis (pwMS), potentially improving cognitive function. Future studies should include individuals with lower CSA engagement and track progress to maintain motivation.

Keywords:
AcceptabilityCognitive rehabilitationCognitive reserveCognitive trainingContent analysisFeasibilityMultiple sclerosis

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Area of Science:

  • Neuroscience
  • Cognitive Psychology
  • Rehabilitation Science

Background:

  • Cognitive decline is a concern in multiple sclerosis (MS).
  • High cognitive reserve (CR) may protect against cognitive decline in people with MS (pwMS).
  • Cognitively stimulating activities (CSAs) are thought to build CR and may enhance cognitive function.

Purpose of the Study:

  • To assess the feasibility and acceptability of an intervention designed to increase CSA participation in pwMS.
  • To explore potential benefits and barriers associated with such an intervention.

Main Methods:

  • A 12-week randomized controlled trial intervention.
  • Post-intervention interviews with 14 participants selected for sample diversity.
  • Inductive content analysis of verbatim interview transcripts.

Main Results:

  • The intervention was feasible and acceptable to participants.
  • Reported benefits included subjective cognitive improvements, better awareness of deficits, and use of compensatory strategies.
  • Indirect benefits like improved mood and physical functioning were noted.
  • Barriers included lack of structure, technical issues, time constraints, and adherence guilt, particularly for those with progressive MS, younger age, or high baseline activity.

Conclusions:

  • An individualized intervention to boost CSAs in pwMS is feasible.
  • Future interventions should target individuals with lower CSA engagement and incorporate progress monitoring for sustained motivation.