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Modelling TIP60-YAP signalling in epithelial cell renewal using 3D gastric organoids

Hazrat Ismail1, Zhen Dou1,2, Dongmei Wang1,2

  • 1Ministry of Education Key Laboratory for Membraneless Organelles and Cellular Dynamics, School of Life Sciences, University of Science and Technology of China, Hefei 230027, China.

Journal of Molecular Cell Biology
|May 16, 2025
PubMed
Abstract

No abstract available in PubMed .

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Role Of Notch Signalling In Intestinal Stem Cell Renewal01:12

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Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...

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