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A Method for Screening and Validation of Resistant Mutations Against Kinase Inhibitors
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Atypical Femoral Fracture in a Patient on Imatinib: A Case Report
Amirzeb Aurangzeb1, Kinjal Vidyut Mehta, Siti Mastura Binte Rahim
1Department of Orthopaedic Surgery, Changi General Hospital, Singapore.
Case:
A 74-year-old woman with chronic myeloid leukemia on long-term imatinib therapy and a history of bisphosphonate use presented with an atypical femoral fracture after low-energy trauma. She underwent staged intramedullary nailing of both femurs.
Conclusion:
This case highlights the potential synergistic effect of bisphosphonates and imatinib on bone metabolism, leading to an increased risk of atypical femoral fractures. Vigilant monitoring of bone health in such patients is crucial for early detection and prevention.
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