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Clinical effect of catheter-directed thrombolysis combined with intermittent pneumatic compression on lower extremity
1Department of Outpatient, Shanxi Provincial People's Hospital, Taiyuan, Shanxi, China.
Aim:
This study investigated the effectiveness of catheter-directed thrombolysis (CDT) combined with intermittent pneumatic compression (IPC) in patients with lower extremity deep venous thrombosis (LEDVT).
Materials And Methods:
A retrospective analysis was conducted on 68 LEDVT patients. Those who received CDT with IPC were assigned to the IPC group, while those who underwent CDT alone were designated as the control group. Both groups were further divided into early and late subgroups based on the time from symptom onset to CDT. Data collected included the cumulative urokinase dosage, CDT duration, and other relevant clinical indicators.
Results:
The cumulative urokinase dosage was lower in the IPC group than in the control group (P<0.05). CDT duration was shorter in the IPC group than in the control group and was also shorter in the early subgroup compared with the late subgroup (all P<0.05). The peak D-dimer occurred earlier in the IPC group than in the control group (P<0.05). The incidence of grade II-III thrombolysis was higher in the IPC group than in the control group on days 2 and 3 of CDT (all P<0.05). The IPC group showed a greater reduction in thigh and calf circumference than the control group on days 3 and 4 of CDT (all P<0.05).
Conclusions:
In LEDVT patients, CDT combined with IPC reduced the cumulative urokinase dosage, shortened CDT duration, promoted earlier deep vein patency, and accelerated the relief of lower extremity swelling.