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Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.

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Harnessing complement biomarkers for precision cancer care.

Houcine Hamidi1, Idris Boudhabhay2, Marie-Agnes Dragon-Durey1

  • 1Centre de Recherche des Cordeliers, Sorbonne Université, Inserm, Université Paris Cité, Inflammation, Complement and Cancer team, Paris, France; Laboratoire d'Immunologie, Hôpital Européen Georges Pompidou, APHP, Paris, France; University Hospital Federation (FHU) COMET, Paris, France.

Seminars in Immunology
|May 16, 2025
PubMed
Summary

The complement system, a key player in the tumor microenvironment, shows potential as a cancer biomarker. Research highlights its role in tumor development, prognosis, and potential for early detection and treatment monitoring.

Keywords:
Body fluids biomarkerCancerComplementImmunostainingTranscriptomic

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Area of Science:

  • Oncology
  • Immunology
  • Biochemistry

Background:

  • The tumor microenvironment (TME) significantly influences cancer progression and treatment outcomes.
  • The complement system, a cascade of proteins, plays a critical role within the TME.
  • Understanding complement's function in cancer is crucial for developing new diagnostic and therapeutic strategies.

Purpose of the Study:

  • To review current data on the complement system's potential as a cancer biomarker.
  • To explore how complement system analysis can aid in cancer detection, staging, and treatment monitoring.
  • To define the evolving role of the complement system in comprehensive cancer management.

Main Methods:

  • Transcriptomic analyses to classify tumors based on complement gene expression and prognostic impact.
  • Immunostaining to visualize complement protein and fragment expression and deposition in tumors and TME.
  • Analysis of complement activation fragments and autoantibodies in body fluids (e.g., blood) for non-invasive biomarker identification.

Main Results:

  • Complement gene expression patterns correlate with tumor prognosis.
  • Complement proteins and fragments are expressed and deposited within tumors and the TME.
  • Circulating complement activation fragments and autoantibodies serve as non-invasive biomarkers for specific cancer types.

Conclusions:

  • The complement system is a promising biomarker in oncology, offering insights into tumor biology and patient prognosis.
  • Complement-based biomarkers can facilitate non-invasive cancer detection, staging, and potentially treatment monitoring.
  • Further research and development of complement-targeting therapies and analytical tools are essential for integrating the complement system into clinical cancer management.