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Updated: May 5, 2026

Regioselective O-Glycosylation of Nucleosides via the Temporary 2',3'-Diol Protection by a Boronic Ester for the Synthesis of Disaccharide Nucleosides
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Regioselective O-Glycosylation of Nucleosides via the Temporary 2',3'-Diol Protection by a Boronic Ester for the Synthesis of Disaccharide Nucleosides

Published on: July 26, 2018

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Acyclic purine and pyrimidine nucleotide analogs as ecto-5'-nucleotidase (CD73) inhibitors

Stephanie Federico1, Christian Renn2, Petra Brehova3

  • 1PharmaCenter Bonn, Pharmaceutical Institute, Pharmaceutical & Medicinal Chemistry, University of Bonn, An der Immenburg 4, D-53121, Bonn, Germany; Department of Chemical and Pharmaceutical Sciences, University of Trieste, Via Licio Giorgieri 1, I-34127, Trieste, Italy.

European Journal of Medicinal Chemistry
|May 16, 2025
PubMed

Keywords:
Acyclic nucleotidesCD73Cancer immunotherapyEcto-5′-nucleotidaseInhibitorsSynthesisX-ray co-crystal structure

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