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Updated: Jul 8, 2026

Visualization of Bacterial Resistance using Fluorescent Antibiotic Probes
Published on: March 2, 2020
1,2,3-Triazole‑gold(I)-triethylphosphine derivatives of nutrients as new antimicrobials against antibiotic resistant
Mathieu Michaut1, Françoise Hoegy2, Alexandre Steffen1
1Prestwick Chemical, PC SAS, 220 Boulevard Gonthier d'Andernach, 67400 Illkirch-Graffenstaden, France.
Abstract:
The ongoing rise of bacterial resistance against antibiotics is an incentive to develop radically new antibacterial molecules. Innovative organo-gold(I) antibacterial compounds were synthesized by click chemistry with triethylphosphine‑gold(I) azides and alkyne-functionalized metabolites like amino acids, nicotinic acid and biotin. The resulting organo‑gold(I) compounds exhibited remarkable activities against a panel of Gram-positive pathogens (Staphyloccocus sp., Enterococcus sp. and Clostridium difficile) but failed to inhibit the growth of Gram-negative bacilli (e.g., Escherichia coli) under the conditions used (8 microg. mL-1 maximum).
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