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Commentary: The association between uric acid to high-density cholesterol ratio and depression: A population-based
Qiuxuan Huang1, Zehao Hu1, Ru Liu1
1Shantou Hospital of Traditional Chinese Medicine, Guangzhou University of Traditional Chinese Medicine, Shantou, 515000, Guangdong, China; Guangzhou University of Traditional Chinese Medicine, Guangdong, Guangzhou, China.
None:
This commentary examines the recent findings by Wang et al. (2025) on the association between the uric acid to high-density lipoprotein cholesterol ratio (UHR) and depression in a U.S. population. While the study demonstrates a significant correlation using cross-sectional data and advanced statistical methods, several methodological limitations warrant discussion. Key concerns include the study's inability to establish causality, unaddressed confounders (e.g., lifestyle factors, medications), and limited generalizability due to its U.S.-centric sample. The self-reported depression measures and lack of longitudinal data further constrain the clinical interpretation. To advance this research, we recommend prospective designs, causal inference methods, and broader population inclusion. These improvements would strengthen UHR's utility as a potential biomarker for depression risk stratification and prevention strategies.
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