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Updated: May 23, 2025
Gastric Mucosa Quantitative Polymerase Chain Reaction Analysis for Detecting Helicobacter pylori and Antibiotic Resistance
Published on: March 7, 2025
Bee products in the fight against Helicobacter pylori and molecular interactions
Hesham R El-Seedi1, Mohamed S Refaey2, Aida A Abd El-Wahed3
1International Research Center for Food Nutrition and Safety, Jiangsu University, Zhenjiang 212013, China; Department of Chemistry, Faculty of Science, Islamic University of Madinah, Madinah 42351, Saudi Arabia.
Insights
Bee products offer a promising alternative to antibiotics for eradicating Helicobacter pylori (H. pylori) infection, potentially preventing gastric ulcers and cancer. These natural compounds exhibit antibacterial, antioxidant, and anti-inflammatory properties to combat H. pylori.
Area of Science:
- Microbiology
- Pharmacology
- Gastroenterology
Background:
- Helicobacter pylori (H. pylori) infection is a leading cause of gastric ulcers and gastric cancer worldwide.
- Current antibiotic treatments for H. pylori face challenges like recurrence, resistance, and overuse.
- There is a need for alternative therapeutic strategies to manage H. pylori infections and their complications.
Purpose of the Study:
- To explore the potential of bee products as an alternative treatment for H. pylori infection.
- To review the mechanisms by which bee products exert their effects against H. pylori.
- To highlight the therapeutic applications of bee products in preventing H. pylori-related gastrointestinal diseases.
Main Methods:
- Literature screening using databases such as Sci-finder, Google Scholar, PubMed, ScienceDirect, Web of Science, and Scopus.
- Keywords included "helicobacter pylori", "epidemiology", "chemotherapy", "honey", "propolis", "bee venom", "bioactive compounds", and "mechanism of action".
Main Results:
- Bee products possess diverse biochemical and biological characteristics beneficial for treating ailments.
- Proposed mechanisms of action include direct antibacterial effects, antioxidant, anti-inflammatory, and wound healing capacities.
- Bee products may disrupt H. pylori cell membranes and inhibit bacterial virulence factors, potentially preventing adherence to stomach cells.
Conclusions:
- Bee products represent a viable alternative for preventing and eliminating H. pylori infestations.
- The bioactive compounds in bee products offer promising therapeutic applications against H. pylori.
- Further research into bee product-based treatments could address drawbacks associated with conventional antibiotic therapies.
Abstract:
Gastric or duodenal ulcers can lead to upper gastrointestinal (GI) bleeding. Infection with Helicobacter pylori (H. pylori) is one of the most common infections in the world and can cause both gastric ulcers and gastric cancer. The treatment aims to eradicate H. pylori and treatment with antibiotics has made it possible to cure gastric ulcers. The most common complication of untreated peptic ulcer disease is bleeding (hematemesis, melena, and anemia), while perforation occurs in a smaller proportion of patients. In some individuals, the infection causes mucosal changes with increasing age that lead to atrophy and intestinal metaplasia. It is believed that atrophy and especially intestinal metaplasia are a prerequisite for the most common form of gastric cancer, adenocarcinoma. There is presently a demand for an alternate treatment devoid of the current strategies drawbacks including recurrence, resistance and antibiotic abuse. The current workhighlights the possibility of bee product-based treatments for preventing and eliminating H. pylori infestation. Sci-finder, Google Scholar, PubMed, ScienceDirect, Web of Science, and Scopus were used for literature screening. Terms and keywords, i.e. "helicobacter pylori", "epidemiology", "chemotherapy", "honey", "propolis", "bee venom", "bioactive compounds", and "mechanism of action" were used in the search. Bee products are important alternatives that have been utilized for treating many ailments due to their diverse biochemical and biological characteristics. Various mechanisms, such as direct antibacterial, antioxidant, anti-inflammatory, and wound healing capacities, are proposed to explain the potential effect of bee products against H. pylori. The bee product's metabolites have a role in the adherence of H. pylori to stomach epithelial cells. The disruption of bacterial cell membranes and the inhibition of virulence factors are the two mechanisms behind the bee product's promising therapeutic applications against H. pylori.
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