Whole-body magnetic resonance imaging in myxoid liposarcoma: Toward a new standard?

Myxoid/Round cell liposarcoma (MLPS) is the second most common subtype of liposarcoma (LPS), accounting for approximately 5 % of all soft tissue sarcomas (STS). Unlike other LPS subtypes, MLPS is characterized by a distinct pattern of metastasis, often involving bones and soft tissues rather than the lungs. Skeletal metastasis occurs in a significant proportion of MLPS patients, particularly those with high-grade tumors, making early detection critical for optimal management. While MLPS tumors are known to be highly radiosensitive and chemosensitive, current screening strategies for bone metastases remain suboptimal. Recent advancements in imaging, particularly Whole-body magnetic resonance imaging (WBMRI), offer promising potential for enhancing the detection of both bone and soft tissue metastases in MLPS patients. This article explores the clinical utility of WBMRI in MLPS, reviewing its ability to detect metastatic lesions, discussing various imaging protocols, and highlighting supporting data from recent studies. The paper emphasizes the role of WBMRI in improving disease staging, thereby guiding more personalized therapeutic strategies for MLPS patients.