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Metabolic dysfunction-associated kidney disease: pathogenesis and clinical manifestations
Anip Bansal1, Michel Chonchol1
1Division of Renal Diseases and Hypertension, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Kidney International
|May 16, 2025
Summary
Metabolic dysfunction-associated kidney disease (MDAKD) is a growing concern linked to obesity and poor lifestyle. This review emphasizes understanding MDAKD
Area of Science:
- Nephrology
- Metabolic Diseases
- Public Health
Background:
- Lifestyle changes, including high-calorie diets and sedentary habits, are increasing obesity rates.
- Obesity and metabolic dysfunction contribute to serious health issues like cardiovascular and chronic kidney diseases.
- Metabolic dysfunction-associated kidney disease (MDAKD) is a significant complication of metabolic syndrome.
Purpose of the Study:
- To review the clinical features and pathogenesis of MDAKD.
- To highlight the importance of recognizing MDAKD within the spectrum of metabolic diseases.
- To discuss the proposed new nomenclature for conditions driven by metabolic dysfunction.
Main Methods:
- Literature review focusing on recent research and clinical findings related to kidney disease and metabolic dysfunction.
- Analysis of the pathogenesis and clinical characteristics of MDAKD.
- Examination of the evolving terminology in metabolic and kidney disease.
Main Results:
- MDAKD encompasses conditions like diabetic kidney disease and obesity-related kidney disease.
- Metabolic dysfunction, including obesity, insulin resistance, and hypertension, is central to MDAKD.
- New terminology, such as cardio-kidney-metabolic syndrome, reflects the interconnectedness of these conditions.
Conclusions:
- MDAKD is a critical manifestation of metabolic dysfunction impacting kidney health.
- Understanding the pathogenic role of metabolic dysfunction is key to managing MDAKD.
- The new nomenclature underscores the systemic nature of metabolic dysfunction-related diseases.
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