Related Experiment Video

Updated: Jul 16, 2026

A Model for Encephalomyosynangiosis Treatment after Middle Cerebral Artery Occlusion-Induced Stroke in Mice
06:54

A Model for Encephalomyosynangiosis Treatment after Middle Cerebral Artery Occlusion-Induced Stroke in Mice

Published on: June 22, 2022

The role of myeloperoxidase in the pathogenesis of stroke

Wei Liu1, Yi-Ran Wang1, Hongyun Wu2

  • 1First College of Clinical Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China.

Brain Research
|May 16, 2025
PubMed

Insights

Myeloperoxidase (MPO) contributes to stroke by damaging blood vessels and brain tissue through inflammation and oxidative stress. Targeting MPO offers potential new treatments for stroke.

Area of Science:

  • Biochemistry
  • Pathology
  • Neuroscience

Background:

  • Stroke is a major global health issue.
  • Myeloperoxidase (MPO), an enzyme from neutrophils, promotes inflammation and oxidative stress.
  • MPO damages blood vessels, contributing to stroke development and severity.

Purpose of the Study:

  • To review the role of MPO in stroke pathogenesis.
  • To explore MPO's mechanisms in vascular injury, neuroinflammation, and BBB disruption.
  • To discuss MPO-targeted therapies for stroke.

Main Methods:

  • Literature review of MPO's role in stroke.
  • Analysis of MPO's molecular structure and cellular localization.
  • Examination of MPO's involvement in oxidative stress and neuroinflammation.

Main Results:

  • MPO exacerbates cerebral tissue damage post-stroke.
  • MPO is implicated in vascular injury, NET formation, oxidative stress, neuroinflammation, BBB disruption, and neuronal apoptosis.
  • MPO is a reliable prognostic indicator for stroke.

Conclusions:

  • MPO is a key factor in stroke pathogenesis.
  • Understanding MPO's role is crucial for developing effective stroke treatments.
  • MPO-targeted drugs and Traditional Chinese Medicine show therapeutic potential for stroke.
Keywords:
MyeloperoxidaseNeuroinflammationNeutrophilsOxidative StressStrokeTargeted therapyTraditional Chinese Medicine

More Related Videos

The Examination of Peroxidase-Positive Leukocytes in Semen04:36

The Examination of Peroxidase-Positive Leukocytes in Semen

Published on: January 19, 2024

Isolation and Flow Cytometric Assessment of Neuroimmune Interactions in a Mini-Stroke Murine Model08:22

Isolation and Flow Cytometric Assessment of Neuroimmune Interactions in a Mini-Stroke Murine Model

Published on: June 20, 2025

Related Concept Videos

Ischemic Stroke l: Introduction01:15

Ischemic Stroke l: Introduction

Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.
Ischemic Stroke ll: Pathophysiology01:15

Ischemic Stroke ll: Pathophysiology

An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...
Hemorrhagic Stroke l: Introduction01:17

Hemorrhagic Stroke l: Introduction

A hemorrhagic stroke is an acute neurological event that occurs when a weakened cerebral blood vessel ruptures, allowing blood to accumulate within or around the brain. The sudden release of blood forms a focal hematoma that increases intracranial pressure, displaces neural tissue, and can obstruct cerebrospinal fluid pathways. These effects may be compounded by intraventricular extension of the hemorrhage, cerebral edema, or compression of adjacent structures, all of which contribute to...
Hemorrhagic Stroke ll: Pathophysiology01:29

Hemorrhagic Stroke ll: Pathophysiology

A hemorrhagic stroke develops when a cerebral blood vessel ruptures, allowing blood to escape into the surrounding brain tissue, as in intracerebral hemorrhage (ICH), or into the subarachnoid space, as in subarachnoid hemorrhage (SAH). Because the skull is a rigid compartment, the sudden presence of extravascular blood rapidly increases intracranial pressure and compresses adjacent neural structures, leading to immediate tissue injury and impaired cerebral perfusion.Mass Effect and Primary...