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Updated: Jun 15, 2025
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Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma
Published on: November 4, 2010
31.9K
Disease Modification in Severe Asthma-Are We There Yet?
Ian D Pavord1, Stephanie Christenson2, Reynold A Panettieri3
1Respiratory Medicine Unit and Oxford Respiratory NIHR BRC, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom.
Summary
New asthma treatments and biomarkers enable ambitious goals like disease remission. Early, targeted interventions may modify disease progression and reverse damage before irreversible changes occur.
Area of Science:
- Pulmonology and Respiratory Medicine
- Translational Medicine
Background:
- Asthma management is evolving with targeted therapies and accessible biomarkers.
- Current advancements facilitate more ambitious treatment goals, including disease remission.
- Prognostic and predictive biomarkers are driving interest in early, targeted interventions.
Purpose of the Study:
- To define disease modification operationally.
- To review evidence for disease modification in other therapeutic areas.
- To identify key long-term adverse outcomes for prevention and discuss treatment responsiveness.
Main Methods:
- Clinical commentary synthesizing current research and clinical insights.
- Review of existing literature on disease modification and biomarkers in asthma.
- Analysis of mechanisms underlying disease progression and treatment response.
Main Results:
- The concept of disease modification in asthma is explored, aiming to halt or reverse disease.
- Biomarkers are crucial for identifying patients who will benefit from early, targeted interventions.
- Prioritizing prevention of specific long-term adverse outcomes is essential.
Conclusions:
- Early intervention guided by biomarkers holds potential for disease modification in asthma.
- Understanding disease mechanisms is key to optimizing targeted treatment strategies.
- Achieving disease remission and preventing irreversible damage are attainable goals with current advancements.
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