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Related Concept Videos

Brain Imaging01:14

Brain Imaging

Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans),  magnetic resonance imaging (MRI),  functional magnetic resonance imaging (fMRI), and Transcranial Magnetic Stimulation (TMS).
Imaging Studies IV: Magnetic Resonance Imaging01:27

Imaging Studies IV: Magnetic Resonance Imaging

Introduction:Magnetic Resonance Imaging, or MRI, can include a specialized imaging technique of the urinary system known as Magnetic Resonance Urography (MRU). This radiation-free technique uses strong magnetic fields and radio waves to produce detailed images with the help of a computer. MRU is particularly effective for visualizing fluid-filled structures like the kidneys, ureters, and bladder.Applications of MRI in the Genitourinary SystemKidneys and Ureters: MRI detects tumors, cysts,...

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Related Experiment Video

Updated: Jul 15, 2026

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases
09:33

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Published on: July 28, 2013

Mapping Neuroinflammation With Diffusion-Weighted Magnetic Resonance Imaging: A Randomized Crossover Study.

Julia R Plank1, Catherine A Morgan2, Flavio Dell'Acqua3

  • 1School of Pharmacy, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.

Biological Psychiatry. Cognitive Neuroscience and Neuroimaging
|May 16, 2025
PubMed
Summary

Advanced MRI techniques detected brain microstructural changes from inflammation. This non-invasive neuroimaging approach shows promise for studying psychiatric disorders and their inflammatory links.

Keywords:
Diffusion kurtosis imagingDiffusion tensor imagingNeurite orientation density and dispersion imagingNeuroinflammationTyphoid vaccine

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Last Updated: Jul 15, 2026

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases
09:33

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Published on: July 28, 2013

Diffusion Imaging in the Rat Cervical Spinal Cord
10:46

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Published on: April 7, 2015

Advanced Diffusion Imaging in The Hippocampus of Rats with Mild Traumatic Brain Injury
10:33

Advanced Diffusion Imaging in The Hippocampus of Rats with Mild Traumatic Brain Injury

Published on: August 14, 2019

Area of Science:

  • Neuroimaging
  • Neuroinflammation
  • Psychiatric Disorders

Background:

  • Neuroinflammation's role in psychiatric conditions is unclear.
  • Non-invasive in vivo methods are needed to measure neuroinflammation.
  • Diffusion-weighted MRI was explored for detecting low-level neuroinflammation.

Purpose of the Study:

  • To investigate advanced diffusion-weighted MRI techniques for detecting neuroinflammation.
  • To assess potential applications in psychiatric disorders.

Main Methods:

  • A randomized, placebo-controlled, crossover study with 20 healthy volunteers.
  • MRI scans (diffusion tensor, diffusion kurtosis, NODDI) before and after placebo/vaccine.
  • Analysis of thirteen white matter tracts and 15 grey matter regions using region-of-interest and tractography.

Main Results:

  • Global reduction in mean diffusivity (MD) in white matter tracts (p=.040).
  • Increased axial kurtosis in white matter (p<.001) and mean/radial kurtosis in grey matter (p=.038).
  • Correlations observed between interleukin-6 (IL-6) and diffusion parameters.

Conclusions:

  • Diffusion-weighted MRI is sensitive to inflammation-induced microstructural brain changes.
  • This technique may help understand neuroinflammation in psychiatric disorders.
  • Further research integrating complementary methods is recommended.