Bond preservation in caries-affected dentin restored with acrylamide-based adhesives

Area of Science:

• Dental Materials Science
• Biomaterials Engineering
• Caries Research

Background:

• Multi-acrylamides improve adhesive interface stability in sound dentin.
• Caries-affected dentin presents unique challenges for adhesive bonding due to demineralization and collagen degradation.

Purpose of the Study:

• To evaluate triacrylamides as primers for enhancing bonding efficacy in caries-affected dentin (CAD).
• To compare the performance of triacrylamides with conventional primers in both sound (SD) and caries-affected dentin.

Main Methods:

• Caries-affected dentin was created using a microcosm biofilm model.
• Primers containing triacrylamides (TAAEA, TMAAEA) or HEMA were tested with a three-step etch-and-rinse adhesive.
• Microtensile bond strength (μTBS), collagen degradation, and in situ zymography were assessed after 24 hours and six months.

Main Results:

• Triacrylamides maintained high bond strength (>50 MPa) in both SD and CAD after six months.
• HEMA showed significantly lower bond strength (<40 MPa) in CAD.
• Acrylamides mitigated collagen degradation in CAD by reducing enzymatic activity.

Conclusions:

• Multi-acrylamides effectively preserve collagen integrity and sustain bond strength in caries-affected dentin.
• These findings suggest triacrylamides enhance the longevity and performance of dental adhesive restorations.