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Updated: May 20, 2025

Performing Data Mining And Integrative Analysis Of Biomarker in Breast Cancer Using Multiple Publicly Accessible Databases
Published on: May 17, 2019
Gene expression and agent-based modeling improve precision prognosis in breast cancer
Padmasri Sridharan1, Mini Ghosh2
1Department of Mathematics, School of Advanced Sciences, Vellore Institute of Technology, Chennai, 600127, India.
Abstract:
Breast cancer survival is hard to predict because of the complex ways genes and cells interact. This study offers a new method to improve these predictions by combining gene expression profiling (GEP) with agent-based modeling (ABM). First, GEP will pinpoint genes that are important in breast cancer development. Then, a mathematical model will be built to show how these genes influence cell behavior. This data will be used in ABM to simulate tumor growth and treatment response. The ABM allows us to virtually test different treatments and see how they might affect patient survival. Finally, the model's accuracy will be checked against real patient data and compared to other models. By combining the strengths of GEP and ABM, this research could significantly improve breast cancer survival prediction. ABM's ability to analyze interactions mathematically could pave the way for more personalized and effective treatments.
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