Some remarks on preinvasive cervical neoplasia--an image analysis study

By means of automated microscope image analysis 5275 normal cells as well as dyscaryotic cells were investigated in cytologic preparations from 53 cervical smears (26 negative cases, 27 positive cases). In this way, visually not conspicuous differences between normal cell populations of positive and negative cases could be demonstrated with multivariate statistic analysis of discriminant features. The examination of this phenomenon in 2910 epithelial cells from tissue sections of portio conizations has shown that the subvisually changed epithelial cells originate from circumscript regions in the margin and surroundings of CIN-lesions. The biological role of these changes in the formal genesis of cervical neoplasias has been discussed.