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Fabrication and Characterization of a Conformal Skin-like Electronic System for Quantitative, Cutaneous Wound Management

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Nano-Engineered Hybridized Polymeric Framework for Chronic Wound Management.

Anbuthiruselvan Solaimuthu^1,2, Padmaja Murali^1,2, Ane Nishitha Vijayan^1,2

¹Biological Materials Laboratory, CSIR-Central Leather Research Institute (CSIR-CLRI), Sardar Patel Road, Adyar, Chennai, 600020, Tamil Nadu, India.

AAPS Pharmscitech

|May 16, 2025

Summary

A novel hybrid polymeric framework enhances chronic wound healing. This advanced scaffold promotes tissue repair and exudate absorption, offering a promising solution for diabetic wound management.

Keywords:

diabetic foot ulcer drug delivery electrospinning hybrid dressing

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Optimizing Extracellular Vesicle Delivery Using a Core-Sheath 3D-Bioprinted Scaffold for Chronic Wound Management

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Published on: February 28, 2025

Area of Science:

Biomaterials Science
Regenerative Medicine
Nanotechnology

Background:

Chronic wounds, especially diabetic ones, present a major healthcare challenge.
Current treatments often struggle with persistent non-healing, impacting millions globally.
The projected rise in diabetes cases necessitates innovative wound management solutions.

Purpose of the Study:

To design and fabricate a nano-engineered hybridized polymeric framework (HPF) for improved chronic wound healing.
To incorporate therapeutic agents (metformin and aceclofenac) for enhanced efficacy.
To evaluate the physico-chemical, biochemical, and biological properties of the developed scaffold.

Main Methods:

Fabrication of a multi-component scaffold using Polyvinylidene fluoride (PVDF), Collagen/Polyvinyl Alcohol (PVA), and polyhydroxybutyrate (PHB).
Loading metformin hydrochloride and aceclofenac into specific layers of the scaffold.
Characterization using electron microscopy, drug release studies, swelling tests, and in-vitro biological assays (cell viability, hemocompatibility, wound contraction, antioxidant activity).

Main Results:

The HPF scaffold exhibited a porous structure facilitating significant drug release (metformin 72.2%, aceclofenac 63.9% in 24h).
Demonstrated optimal swelling (150-200%) for drug delivery and effective exudate absorption.
Showcased high cell viability (93.5%), hemocompatibility (98.7%), in-vitro wound contraction (73.9%), and enhanced antioxidant activity.

Conclusions:

The nano-engineered hybrid polymeric framework shows significant potential for chronic wound management.
The scaffold's properties support tissue repair and offer a holistic approach to healing.
This advanced material presents a promising therapeutic strategy for non-healing wounds, particularly in diabetic patients.