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Acute pancreatitis experimental models, advantages and disadvantages
Genaro J Rosales-Muñoz1,2, Verónica Souza-Arroyo2,3, Leticia Bucio-Ortiz2,3
1Posgrado en Biología Experimental, Universidad Autónoma Metropolitana-Iztapalapa, Mexico City, Mexico.
Journal of Physiology and Biochemistry
|May 16, 2025
Summary
This review analyzes experimental models for inducing acute pancreatitis (AP), a severe condition. It guides researchers by detailing the pros and cons of current methods for studying AP.
Area of Science:
- Gastroenterology and Hepatology
- Experimental Pathology
- Translational Medicine
Background:
- Acute pancreatitis (AP) is a severe, life-threatening condition with complex pathophysiology.
- Current experimental models often fail to fully replicate human AP's clinical presentation.
- The pancreas's vulnerability complicates disease modeling.
Purpose of the Study:
- To review and analyze current experimental methods for inducing acute pancreatitis.
- To highlight the advantages and disadvantages of each induction model.
- To provide a guide for researchers selecting appropriate AP models.
Main Methods:
- Systematic review of experimental models for acute pancreatitis induction.
- Analysis of methods based on advantages, disadvantages, and suitability for research objectives.
- Comparative evaluation of existing pancreatitis induction techniques.
Main Results:
- Identification of key experimental models used in AP research.
- Detailed comparison of the strengths and weaknesses of each model.
- Assessment of model limitations in relation to experimental goals.
Conclusions:
- Optimized experimental models are crucial for advancing AP research.
- Understanding model limitations is essential for accurate translational studies.
- This review serves as a practical guide for selecting appropriate AP induction methods.
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Pancreatitis is inflammation of the pancreas, an organ located behind the stomach. It can be either acute or chronic.
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