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Preoperative predictors of endometrial carcinoma in patients undergoing hysterectomy for endometrial intraepithelial neoplasia

  • 0Gynecologic Oncology Surgery Clinic, Basakşehir Cam and Sakura City Hospital, Istanbul, 34480, Turkey. nccaltek@gmail.com.
Bmc Cancer +

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May 16, 2025

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May 16, 2025

View abstract on PubMed

Summary

This summary is machine-generated.

Preoperative predictors like age, BMI, and endometrial thickness can identify patients with endometrial intraepithelial neoplasia (EIN) who may have concurrent endometrial cancer (EC) and require lymph node dissection.

Area Of Science

  • Gynecologic Oncology
  • Surgical Pathology
  • Oncology

Background

  • Endometrial intraepithelial neoplasia (EIN) surgery often reveals concurrent endometrial cancer (EC).
  • Lymph node dissection (LND) is sometimes necessary during surgery for EIN.
  • Preoperative identification of EC risk and need for LND is crucial.

Purpose Of The Study

  • To predict the presence of concurrent endometrial cancer (EC) in patients diagnosed with EIN.
  • To identify patients with EIN who may require lymph node dissection (LND) preoperatively.

Main Methods

  • Retrospective analysis of 172 patients with EIN undergoing surgery.
  • Demographic, imaging, clinical, surgical, and pathology data were collected.
  • Statistical analyses included t-tests, Mann-Whitney U tests, odds ratios, and Fisher's exact test.

Main Results

  • Of 172 patients, 71 (41.3%) had EC. Age ≥50, diabetes, and hypertension were associated with EC.
  • Age ≥50, BMI ≥35 kg/m², postmenopausal status, diabetes, hypertension, and endometrial thickness (ET) ≥14 mm predicted occult EC.
  • ET ≥14 mm increased EC likelihood fourfold (aOR: 4.06). 62% of EC patients met criteria for LND.

Conclusions

  • Age ≥50, postmenopausal status, diabetes, hypertension, BMI ≥35 kg/m², and ET ≥14 mm are significant predictors of concurrent EC.
  • Patients with these risk factors should be referred to gynecologic oncology for potential lymph node assessment.
  • This includes consideration for lymphadenectomy or sentinel lymph node biopsy.

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