Related Experiment Video
Updated: Jul 20, 2026

Drug-induced Sensitization of Adenylyl Cyclase: Assay Streamlining and Miniaturization for Small Molecule and siRNA Screening Applications
Published on: January 27, 2014
Evaluation of a DIC Broad Consent Cohort
Marvin O Kampf1, Hans-Ulrich Prokosch2, Christian Gulden2
1Medical Center for Information and Communication Technology, Universitätsklinikum Erlangen, Erlangen, Germany.
Abstract:
This single-center retrospective observational study accesses potential differences between adult patients who were admitted to the University Hospital Erlangen between March 2021 and December 2023 (hospital cohort) and adult patients who have given consent to use their documented data for research purposes (broad consent cohort). Demographic and clinical data (ICD-10 diagnoses) were extracted from the university hospital's FHIR research data repository and analyzed in pseudonymized form. The two cohorts comprise 98,564 and 1,678 patients respectively and were compared concerning representativity of the BC cohort. The results suggest that the ongoing stepwise rollout of the consent obtainment process creates biases in clinical and demographic characteristics. For as long as these biases persist, we suggest researchers to prefer federated over centralized approaches to data analysis, where broad consent is not required and the analyses can be based on the total hospital cohort.
Related Concept Videos
Clinical Trials: Overview
Dose-Response Relationship: Overview
Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast, controlled...
Bioavailability Study Design: Single Versus Multiple Dose Studies
Bioavailability Study Design: Healthy Subjects Versus Patients
Study Designs in Epidemiology
Observational studies are those where the researcher does not intervene but rather observes natural variations. They include cross-sectional, cohort, and case-control studies.
