Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Blind Procedures02:07

Blind Procedures

Ideally, the people who observe and record the children’s behavior are unaware of who was assigned to the experimental or control group, in order to control for experimenter bias. Experimenter bias refers to the possibility that a researcher’s expectations might skew the results of the study. Remember, conducting an experiment requires a lot of planning, and the people involved in the research project have a vested interest in supporting their hypotheses. If the observers knew which child was...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The dominant role of geriatrics vulnerabilities and comorbidities in readmissions after colorectal surgery: Shifting from "nonmodifiable" to "actionable" risk.

Surgery·2026
Same author

Development and Implementation of a Radiation Safety Screening Protocol for a Clinical Study Using Amyloid Positron Emission Tomography Imaging.

Ochsner journal·2026
Same author

Rehospitalization and the Association of Postoperative Delirium With Cognitive Decline in Older Adults.

JAMA internal medicine·2026
Same author

Cognitive Trajectories After Major Surgery in Older Adults and Factors Associated With Severe Decline.

Journal of the American Geriatrics Society·2026
Same author

A Multimodal Approach for Study Diagnosis of MCI and Dementia in the Successful Aging After Elective Surgery (SAGES) Cohort.

The American journal of geriatric psychiatry. Open science, education, and practice·2026
Same author

Defining a Non-Inferiority Margin for Delirium Resolution in a Clinical Trial of Older Adults With Bacteriuria and Abnormal Urine Tests.

Journal of the American Geriatrics Society·2026

Related Experiment Video

Updated: Jun 10, 2026

Development of a Virtual Reality Assessment of Everyday Living Skills
10:32

Development of a Virtual Reality Assessment of Everyday Living Skills

Published on: April 24, 2014

Better Assessment of Illness Study (BASIL) II for Delirium Severity: Study Design, Variables, and Methods.

Tammy T Hshieh1,2,3, Benjamin A Chapin4,5, Wingyun Mak6,7

  • 1Hebrew SeniorLife, Hinda and Arthur Marcus Institute for Aging Research, Boston, MA, USA.

Journal of Geriatric Psychiatry and Neurology
|May 17, 2025
PubMed
Summary

This study validates two new tools, DEL-S and DEL-S-AD, to accurately measure delirium severity in older adults, including those with Alzheimer's Disease and Related Dementias (ADRD). These instruments aim to improve care and research for cognitively impaired populations.

Keywords:
Alzheimer’s dementia and related disordersdeliriumdelirium severitydementiavalidation

More Related Videos

A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment
12:18

A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment

Published on: January 11, 2020

Polar Histogram Visualization of Acute Stress Disorder Scale Scores for Comprehensive Clinical Assessment
08:25

Polar Histogram Visualization of Acute Stress Disorder Scale Scores for Comprehensive Clinical Assessment

Published on: December 6, 2024

Related Experiment Videos

Last Updated: Jun 10, 2026

Development of a Virtual Reality Assessment of Everyday Living Skills
10:32

Development of a Virtual Reality Assessment of Everyday Living Skills

Published on: April 24, 2014

A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment
12:18

A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment

Published on: January 11, 2020

Polar Histogram Visualization of Acute Stress Disorder Scale Scores for Comprehensive Clinical Assessment
08:25

Polar Histogram Visualization of Acute Stress Disorder Scale Scores for Comprehensive Clinical Assessment

Published on: December 6, 2024

Area of Science:

  • Gerontology
  • Neuroscience
  • Clinical Medicine

Background:

  • Delirium is a common, preventable complication of hospitalization and illness.
  • Older adults, especially those with Alzheimer's Disease and Related Dementias (ADRD), are highly vulnerable to delirium and its severe outcomes.
  • Existing assessment tools do not specifically address delirium severity in patients with dementia.

Purpose of the Study:

  • To validate two novel delirium severity instruments: the Delirium Severity (DEL-S) rating for all older adults and the Delirium Severity Rating in ADRD (DEL-S-AD) for patients with dementia.
  • To assess the performance of DEL-S and DEL-S-AD items in older adults with varying cognitive function.
  • To provide accurate measurement of delirium severity for clinical and research applications.

Main Methods:

  • Prospective cohort study (Better ASsessment of ILlness II - BASIL II) across three clinical sites: medical inpatients, elective surgery inpatients, and skilled nursing facility residents.
  • Evaluation of psychometric characteristics, harmonization, and validation of DEL-S and DEL-S-AD against reference standard diagnoses.
  • Inclusion of participants with cognitive function ranging from no impairment to moderate impairment.

Main Results:

  • Validation of the DEL-S and DEL-S-AD instruments for measuring delirium severity.
  • Demonstration of the instruments' utility across a spectrum of cognitive impairment in older adults.
  • Establishment of reliable tools for assessing a critical, graded outcome in vulnerable patient populations.

Conclusions:

  • The DEL-S and DEL-S-AD instruments offer accurate measurement of delirium severity, a crucial outcome measure.
  • DEL-S-AD has significant potential for monitoring delirium in clinical settings and as an outcome in treatment trials for individuals with and without ADRD.
  • These validated tools can improve healthcare for the growing global population of older adults with cognitive impairment.