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A narrative review of metabolomics approaches in identifying biomarkers of doxorubicin-induced cardiotoxicity

  • 0Department of Environmental Health Sciences, Fay W. Boozman College of Public Health, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Metabolomics : Official Journal of the Metabolomic Society +

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May 17, 2025

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May 17, 2025

View abstract on PubMed

Summary

This summary is machine-generated.

Metabolomics research reveals common metabolic alterations in doxorubicin-induced cardiotoxicity (DIC) across various models. Identifying these metabolic biomarkers could lead to early detection and prevention strategies for cancer patients.

Area Of Science

  • Biochemistry
  • Oncology
  • Cardiology

Background

  • Anthracyclines, like doxorubicin, are vital cancer treatments but can cause cardiotoxicity.
  • Currently, no validated biomarkers predict early doxorubicin-induced cardiotoxicity (DIC).
  • Metabolomics offers potential for identifying early DIC biomarkers, but pre-clinical model variations hinder clinical translation.

Purpose Of The Study

  • To systematically review metabolomics studies on DIC across in vitro, animal, and clinical models.
  • To identify and compare metabolite patterns associated with DIC.
  • To map perturbed metabolites to pathways for understanding pathological implications.

Main Methods

  • Systematic literature search of metabolomics studies on DIC (2000-2024).
  • Analysis of metabolites identified across diverse study models (in vitro, animal, clinical).
  • Metabolite Set Enrichment Analysis (MSEA) to identify significantly enriched metabolic pathways.

Main Results

  • 28 studies utilizing LC-MS, GC-MS, and NMR were reviewed.
  • Commonly perturbed metabolites included inosine, phenylalanine, arginine, and tryptophan.
  • Carnitine, purine, and pyrimidine metabolism were most affected; arginine biosynthesis, citrate cycle, and alanine, aspartate, and glutamate metabolism pathways were significantly enriched.

Conclusions

  • Metabolomics shows promise for identifying early DIC biomarkers.
  • Findings provide a foundation for developing strategies to prevent cardiotoxicity.
  • Future research should focus on precise models to bridge the gap between preclinical and clinical studies for biomarker discovery.

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