Novel polysaccharide-based fluorescent polymer drug delivery systems with natural extracts for squamous cell...

This study introduces a novel synthesis method for a new coordination polymer (CP) based on N-donor and O-donor organic ligands. The polymer, with the chemical formula Co(ptda)(bib) (where H₂pdta = 5'-(pyridine-2-yl)-[1,1':3',1'-terphenyl]-4,4'-dicarboxylic acid, bib = 4,4'-bis(1-imidazolyl) biphenyl), was synthesized via solvothermal methods. The structure of the polymer was characterized using single-crystal X-ray diffraction and elemental analysis. Subsequently, a biodegradable polymer-based drug delivery system was constructed, consisting of polyvinyl alcohol (PVA) and polygalacturonic acid (PGA), with potential biomedical applications. For this purpose, PVA-PGA was utilized as the carrier shell in the development of a drug delivery system for compound 1 and Brazilin-loaded CP1 (PVA-PGA@CP1@1@Brazilin). The potential of PVA-PGA@CP1@1@Brazilin as a drug delivery carrier was explored, highlighting its distinct advantages. Furthermore, in vitro cell experiments were conducted to evaluate the therapeutic efficacy of PVA-PGA@CP1@1@Brazilin in the treatment of squamous cell carcinoma (SCC), offering a promising approach for targeted SCC therapy and providing a novel strategy for clinical development.