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Conducting Maximal and Submaximal Endurance Exercise Testing to Measure Physiological and Biological Responses to Acute Exercise in Humans
Published on: October 17, 2018
Influence of endurance versus resistance exercise training on central and peripheral chemoreflexes in young healthy
Thalia Babbage1, Ana L C Sayegh2, Jui-Lin Fan2
1Department of Physiology, Manaaki Manawa - The Centre for Heart Research, Faculty of Medical & Health Sciences, University of Auckland, New Zealand; Department of Anaesthesiology, Faculty of Medical & Health Sciences, University of Auckland, New Zealand.
Abstract:
Heightened central and peripheral chemoreflex sensitivity are associated with poor outcomes, but therapeutic approaches to target them are lacking. Endurance and resistance exercise training improve a multitude of physiological outcomes, but their effects on ventilatory chemoreflex sensitivity are unclear. Accordingly, the cardiorespiratory responses to steady-state isocapnic hypoxia (10 % O2, 5-minutes) and hyperoxic hypercapnic rebreathing (5 % CO2-95 % O2) were compared in endurance, resistance, and untrained groups. Central chemoreflex sensitivity was taken as the slope of the relationship between minute ventilation (V̇E) and end-tidal partial pressure of CO2. Peripheral chemoreflex sensitivity was determined from the absolute increase in V̇E from baseline to peak V̇E expressed relative to the fall in oxygen saturation. Neither central (P = 0.093) nor peripheral (P = 0.847) ventilatory chemoreflex sensitivities were different between groups. Future investigations should seek to understand whether exercise training modality influences central and peripheral chemoreflex sensitivity in older and clinical populations.
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