Related Experiment Video
Updated: Jun 13, 2025
Stereotaxic Infusion of Oligomeric Amyloid-beta into the Mouse Hippocampus
Published on: June 17, 2015
Microinjection of brain-derived neurotrophic factor into the dorsal hippocampus alleviates cognitive dysfunction and
Jinichi Isono1, Osamu Nakagawasai1, Kohei Takahashi2
1Division of Pharmacology, Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University, 4-4-1 Komatsushima, Aoba-ku, Sendai, Miyagi 981-8558, Japan.
Abstract:
Patients with depression show cognitive dysfunction and experience decreased motivation, which interfere with their daily lives. However, whether brain-derived neurotrophic factor (BDNF) in the dorsal hippocampus is involved in depression-associated cognitive deficits is unclear. In this study, olfactory bulbectomized mice, used as a model of depression, showed cognitive dysfunction in the Y-maze and passive avoidance tests and reduction of cell proliferation in the hippocampal dentate gyrus. Microinjection of BDNF into the dorsal hippocampus alleviated the cognitive dysfunction induced by the olfactory bulbectomy and increased hippocampal cell proliferation. This study suggests that BDNF injection in the dorsal hippocampus modulates cognitive functions with cell proliferation in the hippocampal dentate gyrus, thus supporting the importance of hippocampal BDNF in cognitive impairment accompanying depression.
